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Does Metformin Have GLP 1? Exploring the Connection PlexusDx GLP1 Receptor Agonist Therapy and Cardiorenal Outcomes in Patients 80 Years Old With Type 2 Diabetes Chen 2026 Journal of the American Geriatrics Society Wiley Online Library Noom Debuts Microdose GLP 1 Program to Help Reduce Side Effects and Boost Affordability Pharmaceutical Commerce Zepbound to Wegovy GLP 1 GIP Ratio : r Zepbound A Mayo Clinic study found that both metabolic and bariatric surgery and GLP 1 medications improve cardiovascular health in people with obesity, but surgery was associated with significantly greater reductions in long term cardiovascular
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Best in 7 days
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Best in 7 days
Best in 7 days
Best in 7 days
4.5 ★★★★★
Based on 609 reviews
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Product Reviews
★★★★★ 3
These are adorable
Color: Coffe Wood, Color: Coffe Wood
This little frozen treat kit is absolutely adorable. I found 3 different colors for my 3 dogs, so I can tell who got theirs stolen.
First, the kit itself is a 5 star. The little skull, the brain mold, absolutely adorable.
Second, as with a lot of other reviews, what is up with the rope? I had hoped there was a cover for that part of the skull heads when I bought them, then I double checked the reviews and could have had a V8. 🤦🏼♀️ the good news is that once you get the rope off you can replace it with something more washable, if you choose. Rope is a 2 to 3 star.
Third, my dogs don't like these ones as much, that's why the 3 stars. They've tried out 3 different kinds, with a 4th one coming this week. This was their 3rd favorite. They like the ability to carry it by the rope. Getting to the treat through the hole in the bottom isn't "hard", but the skull is tilted on the side, which is exactly what you want to keep your dog entertained, but two of my dogs didn't want to deal with it unless I held it for them. 😒 Dramatic.
Fourth, and finally, I am keeping them. I will probably not put frozen treats in them again, and use it for dry treats or something. So, 3 to 4 stars since I probably won't be able to use the mold for these unless the dogs get used to them.
These little skills have more of a rubber texture to them, making them not really hard plastic, and seemingly more durable. The top, so far, is easy to take off, if you don't have wet hands. There's little divets in the top to help you screw and unscrew thw top. Be careful not to screw it on too tight or too loose. I would take it away from my dogs as soon as I notice they are done with their treats, as I would with dirty dishes. It isn't a toy-toy, more like a treat dispenser.
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Reviewed in the United States on July 13, 2025
★★★★★ 5
Ruff and rugged
Color: Real Bacon&Beef
Ruff and rugged, my dogs chew through everything we get them, not this so far, holding up well against the aggressive chewers.
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Reviewed in the United States on May 18, 2026
★★★★★ 4
Has some flaws but overall not bad
Color: Coffe Wood
I have a 13 pound Jack Russell mix who is an aggressive chewer and gets bored while I am working. I find that a frozen treat situation keeps him busy for 30-45 minutes in his kennel so I can get some quiet time. I've been stuffing the Kong and freezing it, but since I only have one, I have to remember to do it. I liked the option of keeping a bunch of frozen treats to refill the toy at will. I've been eyeballing the Pupsicle brand, but they are really expensive. So for around $10, I figured this was worth a try.
Pros:
So far seems tough. I unscrew it after he finishes the frozen treat so he can lick out the remains, then I take it away from him. I'm sure if I let him he would eventually chew it to shreds.
The design is cute. Although you can't see the fact that the treats are brain shaped once it is in there, it does give me a kick to put a little brain in the skull.
So far no issues with screwing the top of the skull on or taking it off
The inner cavity is quite big. I filled the molds about 3/4 full and there is still a lot of room in the skull. If you have a bigger dog you can fill the molds to the top (just don't over-fill or it won't fit inside)
If you make a big batch of treat filling, you can freeze the rest in those silicone muffin molds, they fit perfectly. Just don't over-fill.
With a 3/4 full mold, made with pumpkin, peanut butter, oats, and a little water, it takes my dog about 45 minutes to get all of the treat out.
Cons:
It's huge and heavy. It's bigger than my dog's skull. But, since he is just trying to eat the brains, it's not like it needs to be lightweight.
The rope is a bad idea. First, it gets gross. Second, my dog has chewed halfway through it already. This seems like a hazard for both choking and bacterial contamination.
The biggest hole is big enough that my dog's bottom jaw gets a little stuck in there. So far he's always able to get it out, but it is a point against the toy.
Overall, its not bad. Not perfect, but serves the function. I'd like to see a slightly smaller, slightly lighter version for dogs under 20 pounds, and lose the rope.
If you do buy this, make sure to take it away from your dog once they have cleaned out the treat.
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Reviewed in the United States on June 5, 2025
★★★★★ 5
Chew on this!
Size: Large
Yes this toy actually is the ONLY one out of 50 others that has lasted longer than a day! He’s happily had this and it keeps him interested! Best one yet!
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Reviewed in the United States on March 24, 2026
★★★★★ 5
Great for aggressive chewers!
This item has held up for 4 months so far! My dog loves it, carries it everywhere. It's one of his favorite toys and he's been through so so many but this is the only one to hold up. However there are CONS! We have dubbed this bone "the cheese grater". My dog loves to bring his toys to us and press them against our legs to get our attention. So after a little chewing, the ends become very rough. When he runs by us with it in his mouth or presses it up against our legs, it tears our skin up! Also, the bone is very heavy so we have to watch out for our toes because Hank will drop it right on our feet if we aren't paying attention. Other than that, it's great! When it gets dirty, I just throw it in the dish washer and rinse it off after the cycle is done. Cleans up nicely! Would buy again if needed! Recommend for aggressive chewers!
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Reviewed in the United States on July 12, 2023
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